NFL 2025: Week 2 - Picks & Predictions

Green Bay Packers vs. Washington Commanders

Date/Time: September 11, 2025, 8:15 PM ET (Lambeau Field, Green Bay, WI)

The Green Bay Packers return home to Lambeau Field for their Thursday night primetime matchup against the Washington Commanders, looking to bounce back from a tough 27–24 loss to the Detroit Lions in Week 1. Quarterback Jordan Love threw for 280 yards and two touchdowns in the opener, showing continued growth as the centerpiece of Matt LaFleur’s offense, but the Packers’ defense faltered against Detroit’s ground game, surrendering 180 rushing yards. Running back Josh Jacobs was a bright spot, rushing for 120 yards and reminding fans why he was one of the team’s headline offseason additions. Christian Watson led the receiving corps with 85 yards, and Romeo Doubs remains a reliable red-zone target, though the offensive line must improve after giving up three sacks. On defense, Rashan Gary provided steady pressure off the edge, and safety Xavier McKinney patrolled the secondary effectively, but early-season metrics place the unit in the bottom half of the league. Green Bay went 5-3 at Lambeau last year and will rely on that home-field advantage to steady the ship, with Love cleared to play despite tweaking his ankle late in the opener.

The Washington Commanders enter Lambeau with momentum after a 21–6 win over the New York Giants in Week 1, a game that showcased both offensive versatility and defensive bite. Rookie quarterback Jayden Daniels lived up to the offseason hype, throwing for 280 yards and three touchdowns while rushing for another 70 yards, proving he can stress defenses with his dual-threat skill set. Terry McLaurin was his go-to option, posting 110 yards and a touchdown, while veteran tight end Zach Ertz contributed 60 yards and another score, demonstrating the balance of Kliff Kingsbury’s scheme. On defense, coordinator Dan Quinn’s unit was relentless, recording five sacks and three takeaways, with Montez Sweat and Jonathan Allen controlling the line of scrimmage. While Washington’s road form was a middling 4-5 in 2024, the early returns on Quinn’s revamped defense suggest this team may finally have the complementary pieces to win in tough environments.

This primetime clash features a fascinating quarterback duel between the steady Love and the electric Daniels. Green Bay’s experience, especially at home in a nationally televised September matchup, gives them a slight edge, but Washington’s playmakers and aggressive defense make them a dangerous opponent. Expect a tightly contested game with explosive moments from both quarterbacks, but Lambeau’s atmosphere and Jacobs’ ability to control the clock tilt the odds in the Packers’ favor.

Score Prediction: Green Bay Packers 27, Washington Commanders 24 (Packers cover -2.5, over 44.5 total points).

Baltimore Ravens vs. Cleveland Browns

Date/Time: September 14, 2025, 1:00 PM ET (M&T Bank Stadium, Baltimore, MD)

The Baltimore Ravens enter Week 2 searching for their first win after a narrow 31–27 defeat to the Buffalo Bills in a primetime opener that showcased both the highs and lows of their roster. Lamar Jackson was outstanding as a passer, throwing for 300 yards and two touchdowns while also adding 50 rushing yards, once again proving why his dual-threat ability is the centerpiece of Baltimore’s offense. Derrick Henry, still proving he has plenty left in the tank, rushed for over 100 yards in his Ravens debut and gave the backfield a punishing presence that complements Jackson’s mobility. The passing game also looked sharp, with Zay Flowers providing explosiveness on the perimeter and Mark Andrews offering his usual reliability over the middle. However, Baltimore’s secondary was exposed by Josh Allen, surrendering four touchdown passes and ranking near the bottom of the league in early pass-defense metrics. At home, though, the Ravens have historically been difficult to beat, going 7–2 at M&T Bank Stadium in 2024, and head coach Mike Macdonald’s schemes should give them a chance to tighten up against Cleveland.

The Cleveland Browns come to Baltimore also at 0–1 after a heartbreaking 17–16 loss to the Bengals in Week 1. Rookie quarterback Dillon Gabriel got the start and showed flashes of composure, throwing for 200 yards and one touchdown, but his two interceptions—including one late in the fourth quarter—proved costly. Fellow rookie Shedeur Sanders remains waiting in the wings, creating an undercurrent of quarterback uncertainty that complicates Cleveland’s offensive rhythm. Nick Chubb continues to be the Browns’ workhorse, rushing for 80 yards in his return from last season’s injury-shortened campaign, but the offensive line struggled mightily, giving up four sacks and failing to establish consistent pass protection. On defense, Myles Garrett looked dominant with two sacks and multiple pressures, reminding everyone why he is one of the NFL’s premier defenders. Still, the unit could not contain Joe Burrow in crunch time, which raises questions about how they will handle Jackson’s escapability and Baltimore’s layered rushing attack.

This AFC North clash feels like a critical early test for both sides. The Ravens’ offensive balance with Jackson and Henry presents a nightmare matchup for a Browns defense that has talent but struggled situationally in Week 1. Meanwhile, Cleveland’s quarterback situation remains unsettled, and facing Baltimore’s aggressive front seven on the road is hardly an ideal environment for a young passer. Unless Chubb can carry the load and Garrett singlehandedly disrupts Jackson, the Ravens appear to hold the clear edge. With a passionate home crowd behind them and urgency to avoid an 0–2 start, Baltimore is well-positioned to dictate the pace and pull away late.

Score Prediction: Baltimore Ravens 28, Cleveland Browns 13 (Ravens cover -10.5, under 43.5 total points).

Cincinnati Bengals vs. Jacksonville Jaguars

Date/Time: September 14, 2025, 1:00 PM ET (Paycor Stadium, Cincinnati, OH)

The Cincinnati Bengals open their home slate at Paycor Stadium fresh off a narrow 17–16 win over the Cleveland Browns in Week 1, a game that highlighted both Joe Burrow’s precision and the defense’s resilience. Burrow threw for 250 yards and two touchdowns without a turnover, looking sharp after last season’s late-year inconsistency. His connection with Ja’Marr Chase, who posted 100 yards in the opener, remains one of the NFL’s most dangerous quarterback-receiver tandems, while Tee Higgins adds another elite downfield option. The ground game, however, still needs traction after Zack Moss managed only 60 rushing yards, and keeping balance against Jacksonville’s front will be a priority. Defensively, Trey Hendrickson made his presence felt with two sacks, anchoring a unit that held Cleveland to just 16 points and looks to be in early-season form. Cincinnati has historically started well at home under Burrow, with a 6–1 record in their last seven home openers, and the combination of offensive firepower and defensive pressure should give them confidence against Jacksonville’s back end.

The Jacksonville Jaguars also come into Week 2 at 1–0 following a hard-fought 23–20 victory over the Carolina Panthers. Trevor Lawrence threw for 220 yards and a touchdown, continuing to show command of Doug Pederson’s system, while Travis Etienne powered the ground attack with 100 rushing yards, keeping the Panthers’ defense off balance. Christian Kirk provided a reliable outlet, and free-agent addition Gabe Davis added another dimension to the receiving corps, giving Lawrence a versatile set of targets. Defensively, Josh Allen (who has officially reverted to his full name, Josh Hines-Allen) recorded a sack and remains the team’s most disruptive force up front, but Jacksonville still allowed 20 points and had trouble containing chunk plays through the air. Their 3–5 road record last season underscores the challenge of traveling into hostile AFC environments, and facing Burrow’s rhythm passing game on the road is one of the stiffest tests of September.

This Week 2 matchup pits two playoff hopefuls with contrasting styles: Cincinnati’s aerial explosiveness against Jacksonville’s ground-first balance. Burrow has historically thrived in early-season home games, and with Chase healthy and Higgins commanding attention, the Bengals’ offense appears poised to stretch Jacksonville’s secondary thin. At the same time, Etienne’s rushing and Lawrence’s steady hand could keep the Jaguars within striking distance, especially if their pass rush can unsettle Burrow. Still, the edge tilts toward Cincinnati, whose home-field advantage and proven big-game weapons are difficult to match in a September afternoon at Paycor.

Score Prediction: Cincinnati Bengals 27, Jacksonville Jaguars 20 (Bengals cover -3.5, over 43.5 total points).

Dallas Cowboys vs. New York Giants

Date/Time: September 14, 2025, 1:00 PM ET (AT&T Stadium, Arlington, TX)

The Dallas Cowboys return home looking to bounce back from a narrow 24–20 loss to the Philadelphia Eagles in Week 1, a game that highlighted both the promise and shortcomings of their roster. Dak Prescott looked sharp and in control, throwing for 280 yards and two touchdowns while spreading the ball efficiently to his playmakers. CeeDee Lamb continued to prove himself as one of the league’s elite receivers with 90 yards, and tight end Jake Ferguson gave Prescott a steady option underneath. However, the run game lacked spark, with veteran Ezekiel Elliott held to just 50 yards on the ground, putting more pressure on Prescott to carry the offense. Dallas’ defense, led by Micah Parsons, generated pressure and forced two turnovers, but still surrendered 24 points, showing that while the unit remains one of the most talented in the league, it is not immune to breakdowns against elite competition. Returning to AT&T Stadium, where the Cowboys went 8–1 in 2024, provides a major advantage, especially against a division rival they have historically dominated, winning nine of their last thirteen meetings with the Giants since 2018.

The New York Giants enter Week 2 at 0–1 after a discouraging 30–16 loss to the Washington Commanders, where rookie quarterback Jaxson Dart made his NFL debut. Dart showed flashes of ability, throwing for 200 yards and a touchdown, but also tossed two costly interceptions and looked overwhelmed at times against Washington’s pressure. Rookie wideout Malik Nabers provided a spark with 80 receiving yards, while Wan’Dale Robinson chipped in as a secondary target, but the offensive line—still one of the team’s biggest concerns—allowed four sacks and struggled to protect Dart consistently. Defensively, the Giants had a tough time containing Jayden Daniels and the Commanders’ balanced attack, conceding 30 points despite strong individual efforts from Brian Burns and Kayvon Thibodeaux. The latter’s rib injury is worth monitoring, as his availability could significantly affect New York’s ability to slow down Prescott and Lamb. On the road, the Giants have struggled historically, posting a 2–6 record in 2024, and they now face a Cowboys team eager to reassert itself at home after a frustrating opening loss.

This matchup looks like another uphill battle for New York, with the Giants relying heavily on their young quarterback to perform in one of the league’s toughest road environments. Dallas’ ability to generate consistent pressure up front with Parsons, combined with Prescott’s chemistry with Lamb, gives them a clear advantage. If Elliott can provide even modest production to keep the offense balanced, the Cowboys should be able to control the game script and force Dart into mistakes. Unless Nabers can break open a big play or the Giants’ pass rush disrupts Prescott’s rhythm, the Cowboys have the upper hand in nearly every phase.

Score Prediction: Dallas Cowboys 30, New York Giants 17 (Cowboys cover -6.5, over 43.5 total points).

Detroit Lions vs. Chicago Bears

Date/Time: September 14, 2025, 1:00 PM ET (Ford Field, Detroit, MI)

The Detroit Lions enter Week 2 at 1–0 after a thrilling 28–24 victory over the Green Bay Packers at Lambeau Field, a game that reaffirmed their standing as one of the NFC’s most explosive offenses. Jared Goff looked in midseason form, throwing for 300 yards and three touchdowns while completing over 70 percent of his passes. His chemistry with Amon-Ra St. Brown, who hauled in 120 yards and a touchdown, continues to be the heartbeat of the Lions’ passing game, while tight end Sam LaPorta picked up right where he left off in his stellar rookie season as a reliable red-zone weapon. On the ground, David Montgomery provided balance with 100 rushing yards, punishing Green Bay’s front seven and keeping the offense multidimensional. Defensively, Detroit showed some vulnerability, surrendering 24 points and over 280 passing yards, but still came up with timely stops when it mattered. The loss of Aidan Hutchinson, who retired after the 2024 season, looms large for Aaron Glenn’s unit, as the Lions are still searching for a consistent pass-rushing identity. Nonetheless, playing at Ford Field, where they went 7–2 last season, gives Detroit confidence, especially with a 3–0 record against Chicago since 2023.

The Chicago Bears also come in at 1–0, fresh off a dramatic 23–20 win over the Minnesota Vikings that marked Caleb Williams’ first NFL victory. The rookie quarterback displayed poise and flashes of brilliance, throwing for 220 yards and two touchdowns while showcasing his ability to extend plays. DJ Moore remained the go-to option, racking up 90 yards and a touchdown, while first-round pick Rome Odunze contributed 70 yards and stretched the field with his speed. The Bears’ offensive line, rebuilt during the offseason, showed improvement by allowing only two sacks, though consistency remains a question against stronger defensive fronts. Defensively, Chicago looked sharp, with Montez Sweat leading the way with two sacks and a constant presence in the backfield. The unit forced one turnover and kept the Vikings under control for most of the second half, ranking top-10 in early defensive efficiency metrics. Still, the Bears’ road record of 3–5 in 2024 suggests a young team that has yet to prove it can consistently win in hostile environments.

This NFC North showdown sets up as one of the week’s most intriguing matchups, pitting the established Lions, who are eyeing another deep playoff run, against the upstart Bears led by their rookie quarterback. Detroit’s experience, offensive versatility, and home-field advantage tilt the balance in their favor, but Williams’ dynamic playmaking gives Chicago a puncher’s chance if the game becomes a shootout. Expect both teams to trade blows offensively, with the Lions’ ability to finish drives ultimately making the difference.

Score Prediction: Detroit Lions 30, Chicago Bears 27 (Lions cover -2.5, over 47.5 total points).

Miami Dolphins vs. New England Patriots

Date/Time: September 14, 2025, 1:00 PM ET (Hard Rock Stadium, Miami Gardens, FL)

The Miami Dolphins return home desperate for a rebound after a humbling 33–8 defeat to the Indianapolis Colts in Week 1, a game where their high-powered offense never found its rhythm. Tua Tagovailoa struggled under relentless pressure, throwing for just 180 yards with one touchdown and two interceptions, while Miami’s offensive line allowed three sacks and looked shaky against Indianapolis’ front. Tyreek Hill flashed his trademark explosiveness with 70 yards on limited touches, while Jaylen Waddle was bottled up for much of the afternoon. Running lanes were scarce, as the Dolphins averaged under four yards per carry, leaving the offense one-dimensional. Defensively, Miami had one of the worst performances of the opening week, surrendering 33 points and over 400 total yards, failing to generate consistent pressure or slow down the Colts’ balanced attack. Still, returning to Hard Rock Stadium, where the Dolphins went 5–3 in 2024, provides a much-needed lift. Miami historically has fared well against New England at home, winning 11 of their last 13 meetings in South Florida, a trend that could prove critical for their bounce-back effort.

The New England Patriots, meanwhile, arrive in Miami at 1–0 following a hard-fought 24–17 victory over the Las Vegas Raiders in Foxborough. Rookie quarterback Drake Maye showed poise in his debut, throwing for 220 yards and two touchdowns while avoiding costly mistakes, giving Patriots fans early optimism about their long-term answer under center. Rhamondre Stevenson powered the ground game with 90 rushing yards, providing balance that kept the Raiders’ defense honest. Defensively, the Patriots looked sharp, forcing two turnovers and controlling the second half behind a secondary anchored by Christian Gonzalez, who limited big plays on the outside. Head coach Jerod Mayo has the defense playing with discipline and physicality, but the road has not been kind to New England, with a 3–6 mark in 2024 away from Gillette Stadium.

This AFC East clash presents a fascinating contrast in styles: Miami’s speed and vertical explosiveness against New England’s patient, ball-control offense and improving defense. If the Dolphins’ offensive line gives Tagovailoa time, Hill and Waddle are mismatches waiting to happen, especially in the Florida heat where New England has traditionally struggled. However, if Maye continues to protect the football and Stevenson establishes the run, the Patriots could grind this into a slower-paced game that keeps Miami’s playmakers on the sideline. The Dolphins’ desperation, home advantage, and track record against New England in Miami ultimately give them the edge, but the Patriots’ young core makes this closer than expected.

Score Prediction: Miami Dolphins 27, New England Patriots 20 (Dolphins cover -3.5, over 43.5 total points).

New Orleans Saints vs. San Francisco 49ers

Date/Time: September 14, 2025, 1:00 PM ET (Caesars Superdome, New Orleans, LA)

The New Orleans Saints enter Week 2 searching for answers after a 28–17 loss to the Arizona Cardinals exposed both offensive inefficiency and defensive lapses. Rookie quarterback Spencer Rattler showed flashes in his debut, completing passes for 200 yards and one touchdown, but he also threw two costly interceptions that stalled momentum. Chris Olave remained the bright spot in the passing game with 80 yards, continuing his role as the offense’s most reliable weapon, while Alvin Kamara chipped in 70 rushing yards and added versatility as a dual-threat back. Still, the Saints were inconsistent in sustaining drives, and red-zone struggles left points off the board. Defensively, the unit gave up four touchdowns, failing to generate consistent pressure up front or clamp down on Arizona’s receivers. Returning home to the Caesars Superdome offers some hope—New Orleans finished 4–4 there in 2024—but the challenge ahead is far stiffer against one of the NFC’s elite.

The San Francisco 49ers come into this matchup with momentum after a hard-fought 27–20 win over the Seattle Seahawks in Week 1, where quarterback Brock Purdy delivered a steady performance with 250 yards and two touchdowns, spreading the ball efficiently to his playmakers. Christian McCaffrey picked up right where he left off last season, eclipsing 100 all-purpose yards and dictating the pace of the offense, while Brandon Aiyuk provided explosive plays on the outside. The absence of George Kittle, sidelined by a hamstring injury, was noticeable at times in the red zone, but Kyle Shanahan’s scheme adjusted with more involvement from secondary targets. Defensively, the 49ers looked like a championship-caliber unit once again. Nick Bosa led the charge with two sacks, anchoring a front that applied constant pressure and held Seattle to just 20 points despite their offensive firepower.

On paper, this matchup leans heavily in San Francisco’s favor. The Saints’ offense, led by a rookie quarterback still adjusting to NFL speed, now faces a defense that thrives on creating chaos and forcing mistakes. Unless Kamara and the run game can establish early rhythm to take pressure off Rattler, New Orleans risks falling behind quickly. The 49ers, meanwhile, have the balance and discipline to control tempo on both sides of the ball, and while their road record in 2024 was only 4–4, their depth and playoff-tested roster give them the clear edge in this matchup. Expect the Saints’ home crowd to keep the energy high early, but San Francisco’s talent should eventually overwhelm.

Score Prediction: San Francisco 49ers 30, New Orleans Saints 17 (49ers cover -6.5, over 43.5 total points).

New York Jets vs. Buffalo Bills

Date/Time: September 14, 2025, 1:00 PM ET (MetLife Stadium, East Rutherford, NJ)

The New York Jets opened their 2025 season with heartbreak, falling 34–32 to the Pittsburgh Steelers in a game that showed flashes of promise but also glaring weaknesses. Aaron Rodgers looked sharp in his return from last year’s injury-shortened campaign, throwing for 300 yards and three touchdowns while displaying chemistry with his playmakers. Garrett Wilson led the receiving corps with a strong outing, continuing to look like a true WR1, and Breece Hall provided balance on the ground with 80 rushing yards. Despite the offensive fireworks, the defense collapsed when it mattered most, giving up 34 points and failing to contain Kenny Pickett in critical moments. The secondary, considered a strength behind Sauce Gardner, surprisingly struggled in coverage breakdowns, raising concerns ahead of a matchup with one of the league’s premier passing attacks. New York’s home form was middling in 2024 at 4–5, but with Rodgers fully healthy and a restless MetLife Stadium crowd, the Jets have the weapons to stay competitive.

The Buffalo Bills, meanwhile, survived a shootout of their own in Week 1, edging the Baltimore Ravens 31–27 in a statement win that reinforced their Super Bowl aspirations. Josh Allen was sensational, throwing for 320 yards and three touchdowns while once again showcasing his dual-threat ability. James Cook provided much-needed stability in the backfield with 100 rushing yards, and Khalil Shakir emerged as a reliable option alongside Stefon Diggs, who continues to be Allen’s go-to target. Defensively, Buffalo still has holes to patch, but edge rusher Greg Rousseau made his presence felt with two sacks, reminding everyone that the Bills’ pass rush can change games even without Von Miller at full strength. The Bills were excellent on the road last season with a 5–3 record, and their ability to travel well adds weight to their status as early-season favorites in the AFC East.

This divisional clash has major implications despite being early in the year. The Jets are desperate to avoid an 0–2 start, particularly with Rodgers under pressure to deliver quickly given the franchise’s long playoff drought. The Bills, on the other hand, know that every division win is critical in an AFC East that looks highly competitive in 2025. Expect Rodgers to test Buffalo’s secondary deep, while Allen will try to exploit the Jets’ shaky coverage from Week 1. Both teams can light up the scoreboard, but Buffalo’s overall balance and Allen’s current form give them the edge in what should be another high-scoring battle.

Score Prediction: Buffalo Bills 28, New York Jets 24 (Bills cover -3.5, over 47.5 total points).

Pittsburgh Steelers vs. Seattle Seahawks

Date/Time: September 14, 2025, 1:00 PM ET (Acrisure Stadium, Pittsburgh, PA)

The Pittsburgh Steelers enter Week 2 riding momentum from a thrilling 34–32 road victory over the New York Jets, a game that gave fans a glimpse of a new offensive identity. Justin Fields, making his Steelers regular-season debut, looked confident and dynamic, throwing for 280 yards and three touchdowns while keeping the Jets’ defense on its heels with his mobility. Najee Harris added balance with 90 rushing yards, proving that Pittsburgh can still lean on the run when needed. However, the win wasn’t without concern: the defense, traditionally the backbone of Mike Tomlin’s teams, surrendered 32 points and allowed Aaron Rodgers to move the ball effectively. T.J. Watt delivered as expected with two sacks, but Pittsburgh will need more consistency across the unit, especially with linebacker Ezekiel Elliott (listed “knee” in reports, but correction: Elliott is a running back, not part of the Steelers) not relevant to injury concerns. At home, the Steelers are a tough out, going 6–2 at Acrisure Stadium in 2024, and with Fields now under center, the atmosphere in Pittsburgh is electric heading into their home opener.

The Seattle Seahawks come into this matchup looking to avoid an 0–2 start after falling 27–20 to the San Francisco 49ers in Week 1. Veteran quarterback Sam Darnold, taking over the offense, had a mixed debut, throwing for 200 yards with one touchdown and one interception while struggling under heavy pressure. The offensive line was a major liability, giving up four sacks and limiting Kenneth Walker III’s effectiveness on the ground, though the young running back still showed flashes of explosiveness. DK Metcalf remained a bright spot, hauling in 80 yards and proving he can win against tight coverage, but the supporting cast struggled to step up. On defense, the Seahawks failed to generate consistent pressure on Brock Purdy, a problem that could be magnified against a mobile quarterback like Fields. Seattle’s road struggles last year, with a 4–5 record, suggest that this trip to Pittsburgh will be a daunting challenge.

This game sets up as a classic strength-versus-weakness battle. The Steelers’ front seven, anchored by Watt and Alex Highsmith, should have opportunities to feast on a vulnerable Seahawks offensive line, forcing Darnold into hurried throws and mistakes. Pittsburgh’s offense has the edge in versatility, with Fields’ dual-threat ability adding a dimension the Seahawks must respect. Seattle will need a near-flawless performance from its defense to keep the game close, but unless the line improves dramatically, it’s hard to see them keeping Fields contained for four quarters.

Score Prediction: Pittsburgh Steelers 24, Seattle Seahawks 17 (Steelers cover -3.5, under 43.5 total points).

Tennessee Titans vs. Los Angeles Rams

Date/Time: September 14, 2025, 1:00 PM ET (Nissan Stadium, Nashville, TN)

The Tennessee Titans begin Week 2 still searching for rhythm after a tough 24–14 opening loss to the Denver Broncos, a game that highlighted both promise and growing pains for rookie quarterback Cam Ward. Making his NFL debut, Ward threw for 180 yards with one touchdown and two interceptions, showing flashes of arm talent but also struggling with decision-making under pressure. Tony Pollard, brought in to be the feature back, managed 70 rushing yards but found little room against Denver’s front, while Calvin Ridley looked sharp in his new role as Tennessee’s top receiver, creating separation even if the connections weren’t always there. The Titans’ offensive line remains a concern, having surrendered three sacks in Week 1, an area that must improve quickly to protect their young quarterback. Defensively, Jeffery Simmons continues to anchor the line, and Tennessee did manage to force one turnover, but giving up 24 points showed that the unit still has work to do. Playing at home is a boost—the Titans went 5–3 at Nissan Stadium in 2024—but Ward will need to settle in quickly against a dangerous opponent.

The Los Angeles Rams, meanwhile, arrive in Nashville with momentum after a hard-fought 27–24 victory over the Houston Texans in Week 1. Matthew Stafford looked as comfortable as ever, throwing for 280 yards and two touchdowns, using his chemistry with breakout star Puka Nacua to devastating effect. Nacua picked up right where he left off in his record-setting rookie campaign, hauling in 100 yards as the clear focal point of the passing game. Running back Kyren Williams continued to be a dual-threat weapon, contributing on the ground and as a receiver, giving the Rams balance offensively. On defense, rookie pass rusher Jared Verse wasted no time making an impact, recording a sack and showcasing why the Rams believe he can be a cornerstone piece in their post-Aaron Donald era. The Rams’ defense isn’t yet the elite unit of their Super Bowl run, but it has enough talent to put stress on a developing quarterback. While Los Angeles was just 4–4 on the road last year, their overall experience and firepower should travel well.

This matchup presents a clear storyline: the battle between an experienced Rams squad and a Titans team navigating the uncertainty of a rookie quarterback. Ward will have to process defenses quicker than he did in Week 1, as Los Angeles’ mix of disguised pressures and athletic edge rushers will test his composure. Pollard and the Titans’ ground game need to establish control to keep the Rams’ offense off the field, but given how sharp Stafford looked to open the season, Tennessee’s defense could be in for a long afternoon if the pass rush doesn’t generate consistent pressure. With Nacua’s reliability, Williams’ versatility, and Stafford’s ability to exploit mismatches, the Rams appear poised to extend their strong start.

Score Prediction: Los Angeles Rams 27, Tennessee Titans 20 (Rams cover -3.5, over 43.5 total points).

Arizona Cardinals vs. Carolina Panthers

Date/Time: September 14, 2025, 4:05 PM ET (State Farm Stadium, Glendale, AZ)

The Arizona Cardinals enter Week 2 riding high after a 28–17 home win over the New Orleans Saints, a game that showcased the balance and versatility of their offense under Kyler Murray. Murray threw for 250 yards and two touchdowns, efficiently spreading the ball to a variety of targets while avoiding turnovers. James Conner anchored the ground game with 100 rushing yards, providing a powerful complement to Murray’s dual-threat capabilities. Tight end Trey McBride was also instrumental, creating mismatches in the middle of the field and contributing key receptions. Defensively, Zaven Collins continues to be a stabilizing force in the linebacker corps, while the unit forced two turnovers to swing momentum and limit New Orleans’ scoring opportunities. Rookie wide receiver Tetairoa McMillan has already made an impression offensively, but Arizona’s overall defense remains opportunistic and capable of exploiting mistakes. The Cardinals’ 5–3 home form in 2024 highlights their ability to perform under the spotlight at State Farm Stadium, giving them a tangible advantage.

The Carolina Panthers, conversely, come off a narrow 23–20 road loss to the Jacksonville Jaguars, a game that exposed ongoing growing pains. Bryce Young threw for 200 yards with one touchdown and one interception, displaying flashes of poise but struggling with consistency under pressure. Running back Chuba Hubbard (80 rush yards) and Rico Dowdle provide balance on the ground, but the Panthers’ offense stalled in key moments and failed to convert drives into touchdowns. Carolina’s defense allowed 23 points, showing vulnerability against both the pass and the run, a concern given Arizona’s multi-dimensional attack. Road struggles persist for the Panthers, who went 3–5 away from home in 2024, suggesting this matchup will be an uphill battle.

This contest shapes up as a battle of momentum versus adjustment. Arizona’s offensive versatility, combined with home-field energy and a defense that can capitalize on mistakes, gives them the upper hand. The Panthers will need Bryce Young to manage the game efficiently, limit turnovers, and lean on Hubbard and Dowdle to sustain drives. Turnovers and third-down efficiency could be the deciding factors, as Arizona has the personnel and home-field advantage to pressure Carolina’s inexperienced offensive line and create mismatches. Expect a moderately paced game, with Arizona’s defense limiting big plays and Murray’s dual-threat ability keeping the Panthers off balance.

Score Prediction: Arizona Cardinals 24, Carolina Panthers 17 (Cardinals cover -3.5, under 43.5 total points).

Indianapolis Colts vs. Denver Broncos

Date/Time: September 14, 2025, 4:05 PM ET (Lucas Oil Stadium, Indianapolis, IN)

The Indianapolis Colts enter Week 2 at 1-0 after a commanding 33–8 home victory over the Miami Dolphins, a performance that showcased their offensive balance and defensive dominance. Anthony Richardson led the charge with 250 passing yards and three touchdowns, demonstrating the dual-threat mobility that makes him one of the league’s most dynamic young quarterbacks. Jonathan Taylor provided a punishing ground attack with 120 rushing yards, complementing Richardson’s playmaking and keeping defenses off-balance. Michael Pittman Jr. remains a reliable target in the passing game, capable of stretching the field and converting critical third downs. The Colts’ defense was equally impressive, forcing three turnovers and recording multiple sacks, building on their top-5 ranking from Week 1. With a 6-2 home record in 2024, Lucas Oil Stadium remains a fortress, giving Indianapolis a strong edge in this early-season AFC showdown.

The Denver Broncos, also 1-0 after a 24–14 win over the Tennessee Titans, bring a balanced offensive attack led by Bo Nix, who threw for 220 yards and two touchdowns in Week 1. Javonte Williams continues to be a workhorse in the backfield, rushing for 90 yards and providing physicality between the tackles, while Courtland Sutton stretches the field as the primary downfield threat. Denver’s defense, anchored by Pat Surtain II (1 interception Week 1) and a front seven that consistently pressures the quarterback, ranks top-5 early in the season and is adept at creating turnovers. Despite a middling 4-4 road record in 2024, the Broncos have the talent and experience to stay competitive in a hostile environment.

This matchup promises a close, high-stakes duel between two of the AFC’s most balanced teams. The Colts’ home-field advantage and explosive offense give them a slight edge, but the Broncos’ opportunistic defense and steady rushing attack suggest the game could come down to turnovers and red-zone execution. Expect both teams to trade scores in the first half, with Indianapolis leveraging Richardson’s dual-threat ability and Taylor’s ground dominance to control the clock late in the game. Key matchups to watch include Richardson vs. Surtain II in coverage, as well as Taylor’s ability to find running lanes against Denver’s disciplined front.

Score Prediction: Indianapolis Colts 27, Denver Broncos 24 (Colts cover -2.5, over 45.5 total points).

Kansas City Chiefs vs. Philadelphia Eagles

Date/Time: September 14, 2025, 4:25 PM ET (Arrowhead Stadium, Kansas City, MO)

The Kansas City Chiefs return to Arrowhead for their Week 2 clash with the Philadelphia Eagles, coming off a narrow 27–21 loss to the Los Angeles Chargers in São Paulo. Patrick Mahomes was efficient in the opener, throwing for 258 yards and one touchdown while also leading the team in rushing with 57 yards. Despite his steady play, the Chiefs’ offense sputtered early, missing an extra point and a two-point conversion attempt—mistakes that loomed large in the six-point defeat. Tight end Travis Kelce remains Mahomes’ most trusted weapon, while rookie wideout Xavier Worthy’s Week 1 ended prematurely with a shoulder injury. His status is questionable heading into this game. Rashee Rice, now eligible after his offseason legal situation was resolved, gives Kansas City a reliable secondary target, and the offensive line will need to tighten up after allowing frequent pressure from the Chargers’ front. Defensively, Chris Jones remains the cornerstone of Steve Spagnuolo’s unit, which held Justin Herbert and the Chargers under 30 points but struggled with situational execution. Arrowhead remains one of the toughest venues in the league, with the Chiefs going 8-1 at home in 2024, and Mahomes has lost just three regular season home games in his career.

The Philadelphia Eagles enter Week 2 with momentum after a 27–24 win over the Green Bay Packers in the season opener at Lincoln Financial Field, a night that also featured their Super Bowl LIX banner unveiling. Jalen Hurts threw for 243 yards and two touchdowns, connecting often with A.J. Brown, who topped 100 yards, and showing chemistry with DeVonta Smith in key third-down situations. Saquon Barkley was equally important, rushing for 97 yards and adding versatility as a receiving threat out of the backfield, giving the Eagles’ offense a balance it lacked in previous seasons. Philadelphia’s defense, rebuilt in the secondary with rookie corner Quinyon Mitchell, forced two turnovers and held Green Bay’s Josh Jacobs in check after halftime. Sean Desai’s group showed flashes of dominance, though the pass rush will need to be sharper to disrupt Mahomes. On the road, the Eagles were 5-3 in 2024, and Hurts has proven capable of winning in hostile environments, including Arrowhead two seasons ago on Monday Night Football.

This matchup doubles as a rematch of Super Bowl LVII and a collision between two franchises that expect to contend for the Lombardi Trophy again in 2025. Mahomes’ improvisation and Kansas City’s home-field edge weigh heavily in simulations, but Philadelphia’s roster continuity and offensive firepower give them a legitimate shot to steal a road win. Betting models tilt toward the Chiefs as narrow favorites, with market spreads around –3.5 to –4 and totals near 48. Expect another tense, high-scoring game decided in the fourth quarter, with Kansas City’s championship pedigree giving them the slightest edge.

Score Prediction: Kansas City Chiefs 28, Philadelphia Eagles 24 (Chiefs cover -3.5, over 47.5 total points).

Minnesota Vikings vs. Atlanta Falcons

Date/Time: September 14, 2025, 8:20 PM ET (U.S. Bank Stadium, Minneapolis, MN)

The Minnesota Vikings enter Week 2 at 0-1 after a narrow 23–20 loss to the Chicago Bears, a game in which rookie quarterback J.J. McCarthy threw for 200 yards, 1 touchdown, and 1 interception. Despite the loss, McCarthy showed poise in the pocket and the ability to make intermediate and deep throws, connecting with star wide receiver Justin Jefferson (90 yards) and Jordan Addison (80 yards) for key plays. The offensive line allowed 2 sacks, but the Vikings’ offensive scheme under Kevin O’Connell emphasized rhythm passing and effective use of play-action. Defensively, Brian Flores’ unit forced one turnover and pressured the quarterback at critical moments, though they allowed 23 points, highlighting room for improvement against dynamic passing attacks. Minnesota’s home form (6-2 in 2024) and a raucous U.S. Bank Stadium crowd should provide an advantage in this primetime matchup.

The Atlanta Falcons, also 0-1 after a 20–23 loss to the Tampa Bay Buccaneers, aim to rebound under rookie quarterback Michael Penix Jr., who threw for 180 yards and 1 touchdown in Week 1. Running back Bijan Robinson (80 rushing yards) anchors the ground game, while wide receiver Drake London provides the primary vertical threat, though his status will be monitored after a minor shoulder concern. Atlanta’s offense struggled in the red zone and faced pressure from Tampa Bay’s defensive front, which limited big plays. Defensively, the Falcons allowed 23 points, demonstrating gaps against efficient passing attacks. Atlanta’s road form (4-5 in 2024) indicates challenges playing in hostile environments, especially against a Vikings team with home-field momentum.

This matchup is likely to be competitive, with Minnesota’s home advantage and slightly more experienced offensive unit giving them a narrow edge. Key factors will include McCarthy’s ability to protect the football against a Falcons’ front seven capable of generating pressure, and the Vikings’ secondary versus Atlanta’s passing targets. Expect the game to feature back-and-forth scoring drives, with the Vikings leveraging play-action and Jefferson’s explosiveness to secure a late-game advantage.

Score Prediction: Minnesota Vikings 27, Atlanta Falcons 23 (Vikings cover -3.5, over 45.5 total points).

Houston Texans vs. Tampa Bay Buccaneers

Date/Time: September 15, 2025, 7:00 PM ET (NRG Stadium, Houston, TX)

The Houston Texans enter Week 2 at 0-1 following a narrow 27–24 loss to the Los Angeles Rams. Quarterback C.J. Stroud showed poise in his first start, throwing for 250 yards and 2 touchdowns, but the offense struggled to sustain drives against pressure. Running back Joe Mixon, expected to be a focal point of the ground game, is sidelined due to a foot/ankle injury, leaving Damien Pierce to carry the load. Wide receiver Stefon Diggs (80 yards in Week 1) provides a reliable downfield target, but the Texans’ offensive line must improve protection, as Stroud faced consistent pressure throughout the opener. Defensively, Houston allowed 27 points, demonstrating vulnerability to both the pass and run despite a solid Week 1 effort. The Texans’ home form (6-2 in 2024) offers a slight edge in terms of crowd support and familiarity, but adjustments are needed to limit big plays.

The Tampa Bay Buccaneers, 1-0 after a 23–20 victory over the Atlanta Falcons, come in with veteran quarterback Baker Mayfield, who threw for 220 yards and 2 touchdowns. The Buccaneers’ offense remains balanced, with Mike Evans (90 yards) stretching the field and Chris Godwin providing consistency in the intermediate passing game. Tampa Bay’s defense, under the guidance of head coach Todd Bowles, forced one turnover in Week 1 and will look to exploit Houston’s weakened backfield without Mixon. The Buccaneers’ road form (4-5 in 2024) is modest, but experience and situational awareness should keep them competitive in a hostile stadium.

Key factors for this matchup include Houston’s ability to establish the run with Pierce and control the clock, and the Buccaneers’ pass rush and secondary containing Stroud’s tendencies under pressure. With both teams relying on young quarterbacks adjusting to pro schemes, expect a tight game with turnovers and situational execution determining the outcome.

Score Prediction: Tampa Bay Buccaneers 24, Houston Texans 20 (Bucs cover -3.5, under 46.5 total points).

Las Vegas Raiders vs. Los Angeles Chargers

Date/Time: September 15, 2025, 10:00 PM ET (Allegiant Stadium, Las Vegas, NV)

The Las Vegas Raiders enter Week 2 at 0-1 after a 24–17 home loss to the New England Patriots. Quarterback Geno Smith completed 200 yards and one touchdown, but the offense struggled to maintain consistency in the red zone. Wide receiver Davante Adams (80 yards in Week 1) remains the primary downfield threat, while tight end Brock Bowers, listed as questionable, could provide a safety valve in short-to-intermediate routes if healthy. Las Vegas’ defense, led by Maxx Crosby (1 sack), allowed 24 points, demonstrating vulnerabilities in coverage and pass rush depth. Despite these struggles, the Raiders’ home form (5-3 in 2024) and familiarity with Allegiant Stadium give them a slight edge, particularly in a primetime matchup.

The Los Angeles Chargers also enter at 0-1, coming off a 24–20 road loss to the Kansas City Chiefs in Week 1. Justin Herbert threw for 250 yards and 2 touchdowns, showcasing his ability to extend plays and create opportunities under pressure. Running back J.K. Dobbins contributed 70 yards on the ground, balancing the attack, while rookie Ladd McConkey showed promise as a secondary receiving option. However, the Chargers are without All-Pro left tackle Rashawn Slater (torn patellar tendon), a significant blow to pass protection and edge stability. Defensively, L.A. allowed 24 points, leaving questions about their ability to generate turnovers and contain opposing quarterbacks without consistent pressure. The Chargers’ road form (4-4 in 2024) suggests they can keep pace but may struggle in hostile environments against a motivated home team.

Key matchups will include the Raiders’ pass rush against Herbert without Slater, the ability of Geno Smith to avoid turnovers under pressure, and which team can control the line of scrimmage to dictate tempo. With both offenses capable of explosive plays but defensive adjustments likely decisive, expect a closely contested game with small margins determining the winner.

Score Prediction: Las Vegas Raiders 23, Los Angeles Chargers 20 (Raiders cover -2.5, under 45.5 total points).